ATP5H Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the ATPase d subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Mitochondrial
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component:  mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; nucleoplasm
Molecular Function:  protein binding; protein-containing complex binding; transmembrane transporter activity
Biological Process:  ATP biosynthetic process; ATP hydrolysis coupled cation transmembrane transport; cellular response to peptide; cristae formation; mitochondrial ATP synthesis coupled proton transport
Reference #:  O75947 (UniProtKB)
Alt. Names/Synonyms: ATP synthase D chain, mitochondrial; ATP synthase subunit d, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial F1F0, subunit d; ATP5H; ATP5JD; ATPase subunit d; ATPQ; My032 protein
Gene Symbols: ATP5H
Molecular weight: 18,491 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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