CYB5R3 Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Isoform 2 is expressed at late stages of erythroid maturation. 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 15 E1|15 39.4 cM
Cellular Component:  cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; mitochondrion
Molecular Function:  ADP binding; AMP binding; cytochrome-b5 reductase activity, acting on NAD(P)H; FAD binding; flavin adenine dinucleotide binding; NAD binding; oxidoreductase activity; protein binding
Biological Process:  cholesterol biosynthetic process; cholesterol metabolic process; lipid metabolic process; oxidation-reduction process; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process
Reference #:  Q9DCN2 (UniProtKB)
Alt. Names/Synonyms: 0610016L08Rik; 2500002N19Rik; B5R; C85115; Cyb5r3; Cytochrome b5 reductase; cytochrome b5 reductase 3; Dia-1; Dia1; diaphorase 1 (NADH); Diaphorase-1; NADH-cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form; NB5R3; WU:AL591952.1-001; WU:AL591952.1-002; WU:AL591952.1-003; WU:Cyb5r3
Gene Symbols: Cyb5r3
Molecular weight: 34,128 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene