G-alpha i3 Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Chromosomal Location of human Ortholog: 1p13.3
Cellular Component:  centrosome; cytoplasm; endoplasmic reticulum membrane; Golgi membrane; heterotrimeric G-protein complex; midbody; nucleolus; nucleoplasm; plasma membrane
Molecular Function:  G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GDP binding; GTP binding; GTPase activity; metal ion binding; protein binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell cycle; cell division; dopamine receptor signaling pathway; GTP metabolic process; negative regulation of adenylate cyclase activity; positive regulation of macroautophagy
Disease: Auriculocondylar Syndrome 1
Reference #:  P08754 (UniProtKB)
Alt. Names/Synonyms: 87U6; ARCND1; FLJ26559; G protein subunit alpha i3; G(i) alpha-3; G-alpha i3; GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding protein G(i) subunit alpha; Guanine nucleotide-binding protein G(i) subunit alpha-3; Guanine nucleotide-binding protein G(k) subunit alpha
Gene Symbols: GNAI3
Molecular weight: 40,532 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Hedgehog Signaling  |  Microtubule Dynamics  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling
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G-alpha i3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein