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DOCK8
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing. Belongs to the DOCK family. Expressed in peripheral blood mononuclear cells (PBMCs). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, misc.; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 19|19 B |
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Cellular Component:
cell leading edge; cell projection; cytoplasm; leading edge membrane; membrane; plasma membrane
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Molecular Function:
guanyl-nucleotide exchange factor activity; protein binding
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Biological Process:
cellular response to chemokine; dendritic cell migration; immunological synapse formation; memory T cell proliferation; negative regulation of T cell apoptotic process; positive regulation of establishment of T cell polarity; positive regulation of GTPase activity; positive regulation of T cell migration; small GTPase mediated signal transduction
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Reference #:
Q8C147
(UniProtKB)
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Alt. Names/Synonyms: 1200017A24Rik; 5830472H07Rik; A130095G14Rik; AI461977; dedicator of cytokinesis 8; Dedicator of cytokinesis protein 8; Dock8
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Gene Symbols: Dock8
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Molecular weight:
238,978 Da
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Basal Isoelectric point:
6.53
Predict pI for various phosphorylation states
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