DOCK8 Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing. Belongs to the DOCK family. Expressed in peripheral blood mononuclear cells (PBMCs). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9p24.3
Cellular Component:  cytoplasm; cytosol; lamellipodium membrane; leading edge membrane
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding
Biological Process:  blood coagulation; cellular response to chemokine; dendritic cell migration; immunological synapse formation; memory T cell proliferation; negative regulation of T cell apoptotic process; positive regulation of establishment of T cell polarity; positive regulation of GTPase activity; positive regulation of T cell migration; small GTPase mediated signal transduction
Disease: Hyper-ige Recurrent Infection Syndrome, Autosomal Recessive
Reference #:  Q8NF50 (UniProtKB)
Alt. Names/Synonyms: 1200017A24Rik; dedicator of cytokinesis 8; Dedicator of cytokinesis protein 8; DOCK8; epididymis luminal protein 205; FLJ00026; FLJ00152; FLJ00346; HEL-205; MRD2; ZIR8
Gene Symbols: DOCK8
Molecular weight: 238,529 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein