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POLS
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. Belongs to the DNA polymerase type-B-like family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage; DNA replication; EC 2.7.7.19; Transferase |
| Chromosomal Location of human Ortholog: 5p15.31 |
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Cellular Component:
Golgi apparatus; nuclear membrane; nucleolus; nucleoplasm; nucleus; TRAMP complex
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Molecular Function:
ATP binding; guanylyltransferase activity; metal ion binding; poly(A) RNA polymerase activity; SMC family protein binding
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Biological Process:
double-strand break repair; mitotic chromosome condensation; mRNA processing; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of 3'-UTR-mediated mRNA stabilization; response to xenobiotic stimulus; RNA 3' uridylation; RNA 3'-end processing; sister chromatid cohesion
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Reference #:
Q5XG87
(UniProtKB)
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Alt. Names/Synonyms: DNA polymerase kappa; DNA polymerase sigma; LAK-1; LAK1; Non-canonical poly(A) RNA polymerase PAPD7; PAP associated domain containing 7; PAP-associated domain-containing protein 7; PAPD7; POLK; POLS; poly(A) RNA polymerase D7, non-canonical; polymerase (DNA directed) sigma; polymerase (DNA-directed) sigma; TENT4A; Terminal guanylyltransferase; Terminal nucleotidyltransferase 4A; Terminal uridylyltransferase 5; Topoisomerase-related function protein 4-1; TRAMP-like complex polyadenylate polymerase; TRF4; TRF4-1; TRF41; TUTase 5; TUTASE5
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Gene Symbols: TENT4A
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Molecular weight:
84,650 Da
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Basal Isoelectric point:
9.55
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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