POLS Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. Belongs to the DNA polymerase type-B-like family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; DNA replication; EC; Transferase
Chromosomal Location of Human Ortholog: 5p15.31
Cellular Component:  Golgi apparatus; nuclear membrane; nucleoplasm; nucleus
Molecular Function:  ATP binding; guanylyltransferase activity; metal ion binding; SMC family protein binding
Biological Process:  double-strand break repair; mitotic chromosome condensation; mRNA processing; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of 3'-UTR-mediated mRNA stabilization; response to drug; RNA 3' uridylation; sister chromatid cohesion
Reference #:  Q5XG87 (UniProtKB)
Alt. Names/Synonyms: DNA polymerase kappa; DNA polymerase sigma; LAK-1; LAK1; Non-canonical poly(A) RNA polymerase PAPD7; PAP associated domain containing 7; PAP-associated domain-containing protein 7; PAPD7; POLK; POLS; poly(A) RNA polymerase D7, non-canonical; polymerase (DNA directed) sigma; polymerase (DNA-directed) sigma; TENT4A; Terminal guanylyltransferase; Terminal nucleotidyltransferase 4A; Terminal uridylyltransferase 5; Topoisomerase-related function protein 4-1; TRAMP-like complex polyadenylate polymerase; TRF4; TRF4-1; TRF41; TUTase 5; TUTASE5
Gene Symbols: TENT4A
Molecular weight: 82,360 Da
Basal Isoelectric point: 9.56  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB