eIF3-alpha Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Belongs to the eIF-3 subunit J family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 2|2 E5
Cellular Component:  cytosol; eukaryotic translation initiation factor 3 complex
Reference #:  Q3UGC7 (UniProtKB)
Alt. Names/Synonyms: 1810016I04Rik; 2700079K05Rik; AA409117; AA409446; C78575; EI3JA; eIF-3-alpha; eIF-3-alpha-A; eIF-3-alpha-B; Eif3; eIF3 p35; eIF3-; eIF3-alpha; eIF3-p; eIF3-p35; Eif3j; Eif3j-1; Eif3j-2; eIF3j-A; eIF3j-B; Eif3j1; Eif3j2; Eif3s1; Eif3s1-1; Eukaryotic translation initiation factor 3 subunit 1; Eukaryotic translation initiation factor 3 subunit 1-A; eukaryotic translation initiation factor 3 subunit 1-B; Eukaryotic translation initiation factor 3 subunit J; Eukaryotic translation initiation factor 3 subunit J-A; eukaryotic translation initiation factor 3, subunit 1 alpha; eukaryotic translation initiation factor 3, subunit J; eukaryotic translation initiation factor 3, subunit J1; OTTMUSP00000016547
Gene Symbols: Eif3j1
Molecular weight: 29,344 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

eIF3-alpha

Protein Structure Not Found.


Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein