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eIF3-alpha
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Belongs to the eIF-3 subunit J family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
| Chromosomal Location of human Ortholog: 15q21.1 |
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Cellular Component:
cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex
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Molecular Function:
identical protein binding; protein binding; translation initiation factor activity
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Biological Process:
formation of cytoplasmic translation initiation complex; translational initiation
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Reference #:
O75822
(UniProtKB)
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Alt. Names/Synonyms: eIF-3-alpha; eIF3 p35; eIF3-alpha; eIF3-p35; EIF3J; EIF3S1; Eukaryotic translation initiation factor 3 subunit 1; Eukaryotic translation initiation factor 3 subunit J; eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD); eukaryotic translation initiation factor 3, subunit 1 alpha, 35kDa; eukaryotic translation initiation factor 3, subunit J
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Gene Symbols: EIF3J
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Molecular weight:
29,062 Da
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Basal Isoelectric point:
4.72
Predict pI for various phosphorylation states
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CST Pathways:
Translational Control
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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