DVL2 a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11 B3|11 42.96 cM
Cellular Component:  aggresome; apical part of cell; cell cortex; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; lateral plasma membrane; membrane; nuclear body; nucleoplasm; nucleus; plasma membrane
Molecular Function:  frizzled binding; identical protein binding; protein binding; protein binding, bridging; protein domain specific binding; protein kinase binding; protein self-association; Rac GTPase binding
Biological Process:  canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in regulation of cell proliferation; cellular protein localization; cochlea morphogenesis; convergent extension involved in neural plate elongation; convergent extension involved in organogenesis; heart development; heart morphogenesis; intracellular signal transduction; multicellular organism development; neural tube closure; non-canonical Wnt signaling pathway; outflow tract morphogenesis; planar cell polarity pathway involved in neural tube closure; positive regulation of DNA-binding transcription factor activity; positive regulation of GTPase activity; positive regulation of JUN kinase activity; positive regulation of protein phosphorylation; positive regulation of protein tyrosine kinase activity; positive regulation of transcription, DNA-templated; protein complex oligomerization; segment specification; segmentation; transcription by RNA polymerase II; Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway
Reference #:  Q60838 (UniProtKB)
Alt. Names/Synonyms: dishevelled 2, dsh homolog (Drosophila); Dishevelled-2; DSH homolog 2; Dvl2; OTTMUSP00000006246; Segment polarity protein dishevelled homolog DVL-2
Gene Symbols: Dvl2
Molecular weight: 78,861 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene