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DVL2
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Belongs to the DSH family. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 17p13.1 |
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Cellular Component:
aggresome; apical part of cell; clathrin-coated endocytic vesicle; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; nuclear body; nucleoplasm; nucleus
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Molecular Function:
frizzled binding; identical protein binding; protein binding; protein domain specific binding; protein kinase binding; protein self-association; protein-macromolecule adaptor activity; small GTPase binding
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Biological Process:
canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in regulation of cell proliferation; cochlea morphogenesis; convergent extension involved in neural plate elongation; heart development; heart looping; intracellular signal transduction; neural tube closure; non-canonical Wnt signaling pathway; outflow tract morphogenesis; planar cell polarity pathway involved in neural tube closure; positive regulation of DNA-binding transcription factor activity; positive regulation of GTPase activity; positive regulation of JUN kinase activity; positive regulation of neuron projection arborization; positive regulation of protein phosphorylation; positive regulation of protein tyrosine kinase activity; positive regulation of transcription by RNA polymerase II; protein localization; regulation of DNA-templated transcription; segment specification; Wnt signaling pathway, planar cell polarity pathway
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Reference #:
O14641
(UniProtKB)
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Alt. Names/Synonyms: dishevelled 2 (homologous to Drosophila dsh); dishevelled segment polarity protein 2; dishevelled, dsh homolog 2; dishevelled, dsh homolog 2 (Drosophila); Dishevelled-2; DSH homolog 2; DVL2; Segment polarity protein dishevelled homolog DVL-2
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Gene Symbols: DVL2
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Molecular weight:
78,948 Da
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Basal Isoelectric point:
5.67
Predict pI for various phosphorylation states
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CST Pathways:
Hippo Signaling
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Microtubule Dynamics
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mTOR Signaling
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Translation: eIF4E and p70S6K
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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