IRS1 an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q36.3
Cellular Component:  caveola; cytoplasm; cytosol; insulin receptor complex; intracellular membrane-bounded organelle; nucleus; plasma membrane
Molecular Function:  insulin receptor binding; insulin-like growth factor receptor binding; phosphatidylinositol 3-kinase binding; phosphotyrosine residue binding; protein binding; protein kinase C binding; SH2 domain binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  cellular response to fatty acid; cellular response to insulin stimulus; glucose homeostasis; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-7-mediated signaling pathway; MAPK cascade; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; phosphatidylinositol 3-kinase signaling; phosphatidylinositol-mediated signaling; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase B signaling; response to insulin; response to peptide hormone; signal transduction
Disease: Diabetes Mellitus, Noninsulin-dependent
Reference #:  P35568 (UniProtKB)
Alt. Names/Synonyms: HIRS-1; Insulin receptor substrate 1; IRS-1; IRS1
Gene Symbols: IRS1
Molecular weight: 131,591 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene