Notch 1 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Heterodimer of a C-terminal fragment N(TM) and an N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation. In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. Belongs to the NOTCH family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor
Chromosomal Location of Human Ortholog: 2 A3|2 18.91 cM
Cellular Component:  acrosomal vesicle; adherens junction; apical plasma membrane; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; Golgi apparatus; integral component of membrane; integral component of plasma membrane; MAML1-RBP-Jkappa- ICN1 complex; membrane; nucleus; plasma membrane; receptor complex
Molecular Function:  calcium ion binding; chromatin binding; chromatin DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; enzyme binding; enzyme inhibitor activity; metal ion binding; Notch binding; protein binding; protein heterodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; transmembrane signaling receptor activity
Biological Process:  angiogenesis; aortic valve morphogenesis; apoptotic process involved in embryonic digit morphogenesis; arterial endothelial cell differentiation; astrocyte differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axonogenesis; branching morphogenesis of an epithelial tube; cardiac atrium morphogenesis; cardiac chamber formation; cardiac epithelial to mesenchymal transition; cardiac left ventricle morphogenesis; cardiac muscle cell proliferation; cardiac muscle tissue morphogenesis; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac septum morphogenesis; cardiac vascular smooth muscle cell development; cardiac ventricle morphogenesis; cell cycle arrest; cell differentiation; cell fate commitment; cell fate specification; cell migration involved in endocardial cushion formation; cellular response to follicle-stimulating hormone stimulus; cellular response to vascular endothelial growth factor stimulus; collecting duct development; compartment pattern specification; coronary artery morphogenesis; coronary sinus valve morphogenesis; coronary vein morphogenesis; determination of left/right symmetry; distal tubule development; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; endocardial cell differentiation; endocardial cushion development; endocardial cushion morphogenesis; endocardium development; endocardium morphogenesis; endoderm development; epidermis development; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; forebrain development; foregut morphogenesis; glial cell differentiation; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart development; heart looping; heart trabecula morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; interleukin-4 secretion; keratinocyte differentiation; left/right axis specification; liver development; lung development; mesenchymal cell development; mitral valve formation; multicellular organism development; negative regulation of anoikis; negative regulation of biomineral tissue development; negative regulation of BMP signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy; negative regulation of catalytic activity; negative regulation of cell death; negative regulation of cell differentiation; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell proliferation; negative regulation of cell proliferation involved in heart valve morphogenesis; negative regulation of cell-substrate adhesion; negative regulation of cold-induced thermogenesis; negative regulation of endothelial cell chemotaxis; negative regulation of extracellular matrix constituent secretion; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of growth rate; negative regulation of inner ear auditory receptor cell differentiation; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neural tube development; neuron differentiation; neuron fate commitment; Notch signaling involved in heart development; Notch signaling pathway; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; osteoblast fate commitment; outflow tract morphogenesis; pericardium morphogenesis; positive regulation of aorta morphogenesis; positive regulation of apoptotic process; positive regulation of apoptotic process involved in morphogenesis; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac epithelial to mesenchymal transition; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell differentiation; positive regulation of ephrin receptor signaling pathway; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glial cell differentiation; positive regulation of JAK-STAT cascade; positive regulation of keratinocyte differentiation; positive regulation of neuroblast proliferation; positive regulation of Notch signaling pathway; positive regulation of Ras protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription of Notch receptor target; positive regulation of transcription, DNA-templated; positive regulation of viral genome replication; prostate gland epithelium morphogenesis; pulmonary valve morphogenesis; regulation of cardioblast proliferation; regulation of cell adhesion involved in heart morphogenesis; regulation of cell migration; regulation of cell proliferation; regulation of developmental process; regulation of epithelial cell proliferation; regulation of epithelial cell proliferation involved in prostate gland development; regulation of extracellular matrix assembly; regulation of gene expression; regulation of inner ear auditory receptor cell differentiation; regulation of neurogenesis; regulation of Notch signaling pathway; regulation of somitogenesis; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; regulation of transcription, DNA-templated; response to muramyl dipeptide; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; skeletal muscle cell differentiation; somatic stem cell division; spermatogenesis; sprouting angiogenesis; tube formation; vasculogenesis involved in coronary vascular morphogenesis; venous blood vessel morphogenesis; venous endothelial cell differentiation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis
Reference #:  Q01705 (UniProtKB)
Alt. Names/Synonyms: 9930111A19Rik; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; Neurogenic locus notch homolog protein 1; NOTC1; Notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1 (Drosophila); Notch1; OTTMUSP00000013754; p300; Tan1; transmembrane receptor Notch1
Gene Symbols: Notch1
Molecular weight: 270,835 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Notch 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene