Notch 1 Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Belongs to the NOTCH family. In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor
Chromosomal Location of human Ortholog: 9q34.3
Cellular Component:  acrosomal vesicle; adherens junction; apical plasma membrane; cell surface; cytosol; endoplasmic reticulum membrane; extracellular region; Golgi membrane; MAML1-RBP-Jkappa- ICN1 complex; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function:  calcium ion binding; chromatin DNA binding; enzyme binding; enzyme inhibitor activity; identical protein binding; Notch binding; protein binding; transcription coactivator activity; transcription regulator activator activity; transmembrane signaling receptor activity
Biological Process:  animal organ regeneration; aortic valve morphogenesis; apoptotic process involved in embryonic digit morphogenesis; arterial endothelial cell differentiation; astrocyte differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axon guidance; branching morphogenesis of an epithelial tube; calcium-ion regulated exocytosis; cardiac atrium morphogenesis; cardiac chamber formation; cardiac epithelial to mesenchymal transition; cardiac left ventricle morphogenesis; cardiac muscle cell myoblast differentiation; cardiac muscle cell proliferation; cardiac muscle tissue morphogenesis; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac septum morphogenesis; cardiac vascular smooth muscle cell development; cardiac ventricle morphogenesis; cell differentiation in spinal cord; cell migration involved in endocardial cushion formation; cellular response to follicle-stimulating hormone stimulus; cellular response to hypoxia; cellular response to tumor cell; cellular response to vascular endothelial growth factor stimulus; cilium assembly; collecting duct development; compartment pattern specification; coronary artery morphogenesis; coronary sinus valve morphogenesis; coronary vein morphogenesis; determination of left/right symmetry; distal tubule development; embryonic hindlimb morphogenesis; endocardial cell differentiation; endocardial cushion morphogenesis; endocardium development; endocardium morphogenesis; endoderm development; epidermal cell fate specification; epithelial cell fate commitment; epithelial cell proliferation; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; forebrain development; foregut morphogenesis; gene expression; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart development; heart looping; heart trabecula morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; immune response; in utero embryonic development; inflammatory response to antigenic stimulus; inhibition of neuroepithelial cell differentiation; interleukin-17-mediated signaling pathway; keratinocyte differentiation; left/right axis specification; liver development; lung development; luteolysis; mesenchymal cell development; mitral valve formation; negative regulation of anoikis; negative regulation of biomineral tissue development; negative regulation of BMP signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy; negative regulation of catalytic activity; negative regulation of cell adhesion molecule production; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of cell proliferation involved in heart valve morphogenesis; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cell-substrate adhesion; negative regulation of cold-induced thermogenesis; negative regulation of collagen biosynthetic process; negative regulation of DNA-templated transcription; negative regulation of endothelial cell chemotaxis; negative regulation of epithelial cell proliferation; negative regulation of extracellular matrix constituent secretion; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of inner ear auditory receptor cell differentiation; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of neurogenesis; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; neural tube development; neuroendocrine cell differentiation; neuronal stem cell population maintenance; Notch signaling involved in heart development; Notch signaling pathway; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; oligodendrocyte differentiation; outflow tract morphogenesis; pericardium morphogenesis; positive regulation of aorta morphogenesis; positive regulation of apoptotic process involved in morphogenesis; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac epithelial to mesenchymal transition; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of keratinocyte differentiation; positive regulation of neuroblast proliferation; positive regulation of Notch signaling pathway; positive regulation of Ras protein signal transduction; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of Notch receptor target; positive regulation of viral genome replication; prostate gland epithelium morphogenesis; protein catabolic process; protein import into nucleus; pulmonary valve morphogenesis; regulation of DNA-templated transcription; regulation of epithelial cell proliferation involved in prostate gland development; regulation of extracellular matrix assembly; regulation of somitogenesis; regulation of stem cell proliferation; regulation of transcription by RNA polymerase II; response to lipopolysaccharide; response to muramyl dipeptide; retinal cone cell differentiation; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; skeletal muscle cell differentiation; somatic stem cell division; spermatogenesis; sprouting angiogenesis; T-helper 17 type immune response; tissue regeneration; transcription by RNA polymerase II; tube formation; vasculogenesis involved in coronary vascular morphogenesis; venous endothelial cell differentiation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis
Disease: Adams-oliver Syndrome 5; Aortic Valve Disease 1
Reference #:  P46531 (UniProtKB)
Alt. Names/Synonyms: AOS5; AOVD1; hN1; Neurogenic locus notch homolog protein 1; NEXT; NICD; NOTC1; Notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch homolog 1, translocation-associated; Notch homolog 1, translocation-associated (Drosophila); notch receptor 1; NOTCH1; TAN1; Translocation-associated notch protein TAN-1
Gene Symbols: NOTCH1
Molecular weight: 272,505 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Notch 1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein