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EST1A
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; EC 3.1.-.-; Hydrolase; Nucleolus |
| Chromosomal Location of human Ortholog: 17p13.3 |
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Cellular Component:
chromosome, telomeric region; cytoplasm; cytosol; nucleolus; nucleus; telomerase holoenzyme complex
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Molecular Function:
DNA polymerase binding; metal ion binding; protein binding; ribonucleoprotein complex binding; RNA binding; RNA endonuclease activity; telomerase RNA binding; telomeric DNA binding
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Biological Process:
mRNA export from nucleus; negative regulation of telomere capping; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of dephosphorylation; regulation of telomerase activity; regulation of telomere maintenance; regulation of telomere maintenance via telomerase
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Reference #:
Q86US8
(UniProtKB)
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Alt. Names/Synonyms: C17orf31; EST1 telomerase component homolog A; EST1-like protein A; EST1A; Est1p-like; Ever shorter telomeres 1A; hSmg5/7a; KIAA0732; SMG-6; Smg-6 homolog; smg-6 homolog, nonsense mediated mRNA decay factor; Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans); SMG6; SMG6 nonsense mediated mRNA decay factor; Telomerase subunit EST1A; Telomerase-binding protein EST1A
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Gene Symbols: SMG6
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Molecular weight:
160,462 Da
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Basal Isoelectric point:
6.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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