USP25
Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. Belongs to the peptidase C19 family. Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USP25b is found in all tissues except heart and skeletal muscle. Isoform USP25m is heart and skeletal muscle specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of mouse Ortholog: 16|16 C3.1
Biological Process: chemokine production; cytokine production; I-kappaB phosphorylation; immune response; interleukin-17-mediated signaling pathway; mRNA metabolic process; negative regulation of ERAD pathway; protein deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; proteolysis; regulation of protein stability; response to oxidative stress; stress-activated protein kinase signaling cascade; ubiquitin-dependent protein catabolic process