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ROPN1
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. Testis specific in adult. Overexpressed in hematologic tumor cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cancer Testis Antigen (CTA); Protein kinase, regulatory subunit |
| Chromosomal Location of human Ortholog: 3q21.1 |
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Cellular Component:
cytoplasm; motile cilium
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Molecular Function:
identical protein binding; protein binding
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Biological Process:
cilium organization; flagellated sperm motility; protein localization to cilium; regulation of protein phosphorylation; sperm capacitation
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Reference #:
Q9HAT0
(UniProtKB)
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Alt. Names/Synonyms: Cancer/testis antigen 91; CT91; DKFZp434B1222; ODF6; outer dense fiber of sperm tails 6; rhophilin associated tail protein 1; Rhophilin-associated protein 1A; RHPNAP1; ROP1A; ROPN1; ROPN1A; ropporin; ropporin, rhophilin associated protein 1; Ropporin-1A; testis secretory sperm-binding protein Li 239w
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Gene Symbols: ROPN1
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Molecular weight:
23,893 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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