STAC Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of human Ortholog: 3p22.3-p22.2
Cellular Component:  cytoplasmic side of plasma membrane; cytosol; extrinsic component of cytoplasmic side of plasma membrane; T-tubule
Molecular Function:  metal ion binding; protein binding; transmembrane transporter binding
Biological Process:  cellular response to heat; positive regulation of cation channel activity; positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; signal transduction; skeletal muscle contraction
Reference #:  Q99469 (UniProtKB)
Alt. Names/Synonyms: FLJ32331; SH3 and cysteine rich domain; SH3 and cysteine-rich domain-containing protein; Src homology 3 and cysteine-rich domain-containing protein; src homology three (SH3) and cysteine rich domain; STAC; STAC1
Gene Symbols: STAC
Molecular weight: 44,554 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein