USP25 Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 21q21.1
Cellular Component:  cytosol; endoplasmic reticulum; nucleus
Molecular Function:  ATPase binding; peptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity involved in negative regulation of ERAD pathway
Biological Process:  cellular protein modification process; negative regulation of ERAD pathway; protein deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; proteolysis; ubiquitin-dependent protein catabolic process
Reference #:  Q9UHP3 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 25; Ubiquitin carboxyl-terminal hydrolase 25; ubiquitin specific peptidase 25; ubiquitin specific protease 25; Ubiquitin thioesterase 25; ubiquitin thiolesterase 25; ubiquitin-specific processing protease 25; Ubiquitin-specific-processing protease 25; UBP25; USP on chromosome 21; USP21; USP25
Gene Symbols: USP25
Molecular weight: 122,218 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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