TBPL1 Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. Belongs to the TBP family. Ubiquitously expressed, with highest levels in the testis and ovary. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6q23.2
Cellular Component:  cytoplasm; transcription factor TFIIA complex
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator activity
Biological Process:  acrosome assembly; dTTP biosynthetic process; positive regulation of transcription by RNA polymerase II; spermatid nucleus differentiation; transcription by RNA polymerase II
Reference #:  P62380 (UniProtKB)
Alt. Names/Synonyms: 21 kDa TBP-like protein; 21-kDA TBP-like protein; MGC:8389; MGC:9620; Second TBP of unique DNA protein; STUD; TATA box binding protein-related factor 2; TATA box-binding protein-like protein 1; TATA box-binding protein-related factor 2; TBP-like 1; TBP-like factor; TBP-like protein 1; TBP-related factor 2; TBP-related protein; TBPL1; TLF; TLP; TLP21; TRF2; TRP
Gene Symbols: TBPL1
Molecular weight: 20,887 Da
Basal Isoelectric point: 9.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene