TES Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. Belongs to the prickle / espinas / testin family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6 A2|6 7.67 cM
Cellular Component:  cell junction; cytoplasm; cytosol; focal adhesion; plasma membrane; protein-containing complex
Molecular Function:  metal ion binding; zinc ion binding
Biological Process:  negative regulation of cell proliferation; regulation of cell proliferation
Reference #:  P47226 (UniProtKB)
Alt. Names/Synonyms: D6Ertd352; D6Ertd352e; OTTMUSP00000025619; Tes; Tes1; TES1/TES2; Tes2; TESS; Testin; testin 2; testin LIM domain protein; testin2; testis derived transcript
Gene Symbols: Tes
Molecular weight: 47,983 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene