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IRS1
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 1 C5|1 42.0 cM |
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Cellular Component:
caveola; ciliary basal body; cytoplasm; cytosol; insulin receptor complex; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
insulin receptor binding; insulin-like growth factor receptor binding; phosphatidylinositol 3-kinase binding; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein kinase C binding; protein-containing complex binding; protein-macromolecule adaptor activity; SH2 domain binding; signaling receptor complex adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity
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Biological Process:
cell migration; cellular response to fatty acid; cellular response to insulin stimulus; epithelial cell migration; insulin receptor signaling pathway; insulin secretion; insulin-like growth factor receptor signaling pathway; lipid catabolic process; mammary gland development; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; negative regulation of somatostatin secretion; phosphatidylinositol 3-kinase signaling; positive regulation of 1-phosphatidylinositol-3-kinase activity; positive regulation of epithelial cell migration; positive regulation of fatty acid beta-oxidation; positive regulation of glucagon secretion; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphorylation; protein kinase B signaling; protein localization to nucleus; regulation of gene expression; response to caffeine; response to insulin; response to peptide hormone; signal transduction
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Reference #:
P35569
(UniProtKB)
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Alt. Names/Synonyms: G972; G972R; Insulin receptor substrate 1; IRS-1; Irs1; OTTMUSP00000017705
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Gene Symbols: Irs1
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Molecular weight:
130,723 Da
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Basal Isoelectric point:
8.97
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Insulin Receptor Signaling
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mTOR Signaling
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PI3K/Akt Signaling
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SAPK/JNK Signaling Cascades
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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