Tip60 iso2
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity. Acetylates RAN at 'Lys-134'. Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Belongs to the MYST (SAS/MOZ) family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus |
Chromosomal Location of human Ortholog: 11q13.1 |
Cellular Component:
chromatin; cytoplasm; cytosol; intracellular membrane-bounded organelle; kinetochore; mitotic spindle pole; MSL complex; NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleosome; nucleus; perinuclear region of cytoplasm; Piccolo NuA4 histone acetyltransferase complex; site of double-strand break; Swr1 complex; transcription regulator complex
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Molecular Function:
acetyltransferase activity; chromatin binding; DNA-binding transcription factor binding; histone acetyltransferase activity; histone H2A acetyltransferase activity; histone H2AK5 acetyltransferase activity; histone H4 acetyltransferase activity; histone H4K16 acetyltransferase activity; metal ion binding; peptide 2-hydroxyisobutyryltransferase activity; peptide butyryltransferase activity; peptide crotonyltransferase activity; peptide-lysine-N-acetyltransferase activity; protein binding; transcription coactivator activity; transcription coregulator activity
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Biological Process:
apoptotic process; cellular response to estradiol stimulus; cellular response to glucose starvation; cellular response to glucose stimulus; cellular senescence; DNA damage response; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair-dependent chromatin remodeling; DNA-templated transcription; double-strand break repair; double-strand break repair via homologous recombination; establishment of mitotic spindle orientation; histone acetylation; histone H2A acetylation; histone H4 acetylation; innate immune response; internal peptidyl-lysine acetylation; lipid droplet disassembly; negative regulation of DNA-templated transcription; negative regulation of double-strand break repair via homologous recombination; negative regulation of interleukin-2 production; negative regulation of transcription by RNA polymerase II; neural tube development; neurogenesis; nucleotide-excision repair; peptidyl-lysine acetylation; positive regulation of attachment of mitotic spindle microtubules to kinetochore; positive regulation of autophagy; positive regulation of circadian rhythm; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; positive regulation of mitotic sister chromatid segregation; positive regulation of myoblast differentiation; positive regulation of protein acetylation; positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of triglyceride biosynthetic process; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of double-strand break repair; regulation of hematopoietic stem cell differentiation; response to ionizing radiation; sperm DNA condensation; spermatid development
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Reference #:
Q92993-2
(UniProtKB)
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Alt. Names/Synonyms: 60 kDa Tat-interactive protein; cPLA(2)-interacting protein; cPLA2; cPLA2 interacting protein; ESA1; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 Tat interactive protein, 60kDa; HTATIP; HTATIP1; K(lysine) acetyltransferase 5; K-acetyltransferase 5; KAT5; Lysine acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; TIP; TIP60; Tip60 iso2; ZC2HC5
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Gene Symbols: KAT5
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Molecular weight:
53,077 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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