RPT1 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 5 A3|5 9.97 cM
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; dendritic spine; nucleus; P-body; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex
Molecular Function:  ATP binding; ATPase activity; hydrolase activity; nucleotide binding; proteasome-activating ATPase activity; protein binding; TBP-class protein binding; transcription factor binding
Biological Process:  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  P46471 (UniProtKB)
Alt. Names/Synonyms: 26S protease regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; 26S proteasome regulatory subunit 7; Mss1; OTTMUSP00000029652; proteasome (prosome, macropain) 26S subunit, ATPase 2; Proteasome 26S subunit ATPase 2; Protein MSS1; PRS7; Psmc2; RPT1
Gene Symbols: Psmc2
Molecular weight: 48,648 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene