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WARS
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - tryptophan; Aminoacyl-tRNA synthetase; EC 6.1.1.2; Ligase; Translation; Translation regulation |
| Chromosomal Location of human Ortholog: 14q32.2 |
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Cellular Component:
cytoplasm; cytosol; nucleus; protein-containing complex
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Molecular Function:
ATP binding; kinase inhibitor activity; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; tryptophan-tRNA ligase activity
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Biological Process:
angiogenesis; negative regulation of cell population proliferation; negative regulation of protein kinase activity; positive regulation of gene expression; positive regulation of protein-containing complex assembly; regulation of angiogenesis; translation; tryptophanyl-tRNA aminoacylation
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Disease: Neurodevelopmental Disorder With Microcephaly And Speech Delay, With Or Without Brain Abnormalities; Neuronopathy, Distal Hereditary Motor, Type Ix
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Reference #:
P23381
(UniProtKB)
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Alt. Names/Synonyms: epididymis secretory sperm binding protein; GAMMA-2; HMN9; hWRS; IFI53; IFP53; Interferon-induced protein 53; SYWC; T1-TrpRS; T2-TrpRS; TrpRS; tryptophan tRNA ligase 1, cytoplasmic; Tryptophan--tRNA ligase; Tryptophan--tRNA ligase, cytoplasmic; tryptophanyl-tRNA synthetase; tryptophanyl-tRNA synthetase 1; Tryptophanyl-tRNA synthetase, cytoplasmic; WARS; WARS1; WRS
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Gene Symbols: WARS1
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Molecular weight:
53,165 Da
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Basal Isoelectric point:
5.83
Predict pI for various phosphorylation states
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