WARS Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Aminoacyl-tRNA synthetase; EC; Ligase; Translation; Translation regulation
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component:  cytoplasm; cytosol; nucleus; protein-containing complex
Molecular Function:  ATP binding; kinase inhibitor activity; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; tryptophan-tRNA ligase activity
Biological Process:  angiogenesis; negative regulation of cell proliferation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; positive regulation of gene expression; positive regulation of protein complex assembly; regulation of angiogenesis; regulation of protein ADP-ribosylation; translation; tRNA aminoacylation for protein translation; tryptophanyl-tRNA aminoacylation
Disease: Neuronopathy, Distal Hereditary Motor, Type Ix
Reference #:  P23381 (UniProtKB)
Alt. Names/Synonyms: GAMMA-2; hWRS; IFI53; IFP53; Interferon-induced protein 53; SYWC; T1-TrpRS; T2-TrpRS; TrpRS; tryptophan tRNA ligase 1, cytoplasmic; Tryptophan--tRNA ligase; Tryptophan--tRNA ligase, cytoplasmic; tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase, cytoplasmic; WARS; WRS
Gene Symbols: WARS
Molecular weight: 53,165 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein