NT-3 Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. Brain and peripheral tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6 F3|6 60.45 cM
Cellular Component:  axon; cytoplasmic vesicle; dendrite; extracellular region; extracellular space; synaptic vesicle
Molecular Function:  chemoattractant activity; growth factor activity; nerve growth factor binding; neurotrophin p75 receptor binding; neurotrophin receptor binding; protein binding; signaling receptor binding
Biological Process:  activation of GTPase activity; activation of MAPK activity; activation of protein kinase B activity; axon guidance; brain development; enteric nervous system development; epidermis development; generation of neurons; glial cell fate determination; induction of positive chemotaxis; mechanoreceptor differentiation; memory; modulation of chemical synaptic transmission; myelination; negative regulation of neuron apoptotic process; negative regulation of peptidyl-tyrosine phosphorylation; nerve development; nerve growth factor signaling pathway; nervous system development; neuromuscular synaptic transmission; neuron development; neuron projection morphogenesis; peripheral nervous system development; positive regulation of actin cytoskeleton reorganization; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of glial cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; regulation of neuron apoptotic process; regulation of neuron differentiation; smooth muscle cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P20181 (UniProtKB)
Alt. Names/Synonyms: AI316846; AI835689; HDNF; Nerve growth factor 2; Neurotrophic factor; neurotrophin 3; Neurotrophin-3; NGF-2; NT-; NT-3; Nt3; Ntf-; Ntf-3; Ntf3
Gene Symbols: Ntf3
Molecular weight: 29,588 Da
Basal Isoelectric point: 9.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene