NT-3 Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. Brain and peripheral tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 12p13.31
Cellular Component:  extracellular region
Molecular Function:  chemoattractant activity; growth factor activity; neurotrophin receptor binding; protein binding; signaling receptor binding
Biological Process:  activation of GTPase activity; activation of MAPK activity; activation of protein kinase B activity; cell-cell signaling; induction of positive chemotaxis; negative regulation of peptidyl-tyrosine phosphorylation; nervous system development; positive chemotaxis; positive regulation of actin cytoskeleton reorganization; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C activity; positive regulation of receptor internalization; regulation of apoptotic process; regulation of signaling receptor activity; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P20783 (UniProtKB)
Alt. Names/Synonyms: HDNF; MGC129711; Nerve growth factor 2; Neurotrophic factor; neurotrophin 3; Neurotrophin-3; NGF-2; NGF2; NT-3; NT3; NTF3
Gene Symbols: NTF3
Molecular weight: 29,355 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein