PGK2 Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis. Belongs to the phosphoglycerate kinase family. Mainly found in round spermatids. Localized on the principle piece in the sperm (at protein level). Testis-specific. Expression significantly decreased in the testis of elderly men. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC; Kinase, other
Chromosomal Location of Human Ortholog: 17 B2|17 19.44 cM
Cellular Component:  cilium; cytoplasm; cytosol; sperm fibrous sheath
Molecular Function:  ADP binding; ATP binding; kinase activity; nucleotide binding; phosphoglycerate kinase activity; transferase activity
Biological Process:  flagellated sperm motility; gluconeogenesis; glycolytic process; phosphorylation; positive regulation of oxidative phosphorylation
Reference #:  P09041 (UniProtKB)
Alt. Names/Synonyms: Pgk-2; Pgk2; Phosphoglycerate kinase 2; Phosphoglycerate kinase, testis specific; Tcp-2
Gene Symbols: Pgk2
Molecular weight: 44,853 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene