ROBO1 Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development. Belongs to the immunoglobulin superfamily. ROBO family. Widely expressed, with exception of kidney. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16|16 C3.1
Cellular Component:  axolemma; axon; cell projection; cell surface; cytoplasm; integral component of membrane; membrane; neuronal cell body; plasma membrane
Molecular Function:  axon guidance receptor activity; identical protein binding; LRR domain binding; protein binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; aorta development; aortic valve morphogenesis; axon guidance; axon midline choice point recognition; cell differentiation; cell migration involved in sprouting angiogenesis; chemorepulsion involved in postnatal olfactory bulb interneuron migration; chemotaxis; coronary vasculature development; endocardial cushion formation; heart development; homophilic cell adhesion via plasma membrane adhesion molecules; mammary duct terminal end bud growth; multicellular organism development; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; negative regulation of mammary gland epithelial cell proliferation; negative regulation of negative chemotaxis; nervous system development; olfactory bulb interneuron development; outflow tract septum morphogenesis; positive regulation of axonogenesis; positive regulation of gene expression; positive regulation of MAP kinase activity; positive regulation of Notch signaling pathway involved in heart induction; positive regulation of Rho protein signal transduction; positive regulation of vascular endothelial growth factor signaling pathway; pulmonary valve morphogenesis; regulation of dendrite morphogenesis; Roundabout signaling pathway; ventricular septum development; ventricular septum morphogenesis
Reference #:  O89026 (UniProtKB)
Alt. Names/Synonyms: AW494633; AW742721; Dutt1; Gm310; OTTMUSP00000018540; Robo1; roundabout guidance receptor 1; Roundabout homolog 1; roundabout homolog 1 (Drosophila)
Gene Symbols: Robo1
Molecular weight: 176,375 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein