ITGB5 Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. Belongs to the integrin beta chain family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16|16 B3
Cellular Component:  cell leading edge; cell surface; focal adhesion; glutamatergic synapse; integral component of membrane; integral component of synaptic membrane; integrin alphav-beta5 complex; integrin complex; membrane; receptor complex
Molecular Function:  integrin binding; protein binding; signaling receptor activity; signaling receptor binding
Biological Process:  cell adhesion; cell adhesion mediated by integrin; cell migration; cell-matrix adhesion; epithelial cell-cell adhesion; integrin-mediated signaling pathway; stress fiber assembly; transforming growth factor beta receptor signaling pathway
Reference #:  O70309 (UniProtKB)
Alt. Names/Synonyms: [b]-5; [b]5; [b]5A; [b]5B; AA475909; AI874634; beta-5; beta5; ESTM23; integrin beta 5; Integrin beta-5; ITB5; Itgb5
Gene Symbols: Itgb5
Molecular weight: 87,909 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene