ITGB5 Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. Belongs to the integrin beta chain family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 3q21.2
Cellular Component:  cell surface; focal adhesion; integrin alphav-beta5 complex; integrin complex; phagocytic vesicle; plasma membrane; receptor complex
Molecular Function:  integrin binding; protein binding; signaling receptor activity; virus receptor activity
Biological Process:  cell adhesion mediated by integrin; cell migration; cell-matrix adhesion; endodermal cell differentiation; epithelial cell-cell adhesion; integrin-mediated signaling pathway; stress fiber assembly; transforming growth factor beta receptor signaling pathway; viral entry into host cell
Reference #:  P18084 (UniProtKB)
Alt. Names/Synonyms: FLJ26658; Integrin beta-5; integrin subunit beta 5; integrin, beta 5; ITB5; ITGB5; testis secretory sperm-binding protein Li 217p
Gene Symbols: ITGB5
Molecular weight: 88,054 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene