ITGB5 Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q21.2
Cellular Component:  cell surface; integrin alphav-beta5 complex; phagocytic vesicle; plasma membrane; receptor complex
Molecular Function:  protein binding; signaling receptor activity; virus receptor activity
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-matrix adhesion; endodermal cell differentiation; epithelial cell-cell adhesion; extracellular matrix organization; integrin-mediated signaling pathway; muscle contraction; stress fiber assembly; transforming growth factor beta receptor signaling pathway; viral entry into host cell
Reference #:  P18084 (UniProtKB)
Alt. Names/Synonyms: FLJ26658; Integrin beta-5; integrin, beta 5; ITB5; ITGB5
Gene Symbols: ITGB5
Molecular weight: 88,054 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ITGB5

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene