AP1B1
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes large subunit family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of mouse Ortholog: 11|11 A1 |
Cellular Component:
AP-1 adaptor complex; clathrin adaptor complex; cytoplasmic vesicle; cytosol; early endosome; Golgi apparatus; intracellular membrane-bounded organelle; lysosomal membrane; membrane; membrane coat; trans-Golgi network; trans-Golgi network membrane
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Molecular Function:
clathrin binding; protein binding; protein kinase binding; protein serine/threonine kinase binding
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Biological Process:
basolateral protein secretion; clathrin coat assembly; determination of left/right symmetry; heart development; intracellular protein transport; kidney development; melanosome assembly; platelet dense granule organization; protein transport; vesicle-mediated transport
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Reference #:
O35643
(UniProtKB)
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Alt. Names/Synonyms: Adapter-related protein complex 1 subunit beta-1; Adaptor protein complex AP-1 subunit beta-1; adaptor protein complex AP-1, beta 1 subunit; Adaptor-related protein complex 1 subunit beta-1; adaptor-related protein complex AP-1, beta 1 subunit; Adtb; Adtb1; AP-1 complex subunit beta-1; Ap1b1; b2b1660C; b2b1660Clo; Beta-1-adaptin; Beta-adaptin 1; beta-prime adaptin; beta1-adaptin; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit
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Gene Symbols: Ap1b1
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Molecular weight:
103,935 Da
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Basal Isoelectric point:
5.04
Predict pI for various phosphorylation states
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