AP1B1 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes large subunit family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11|11 A1
Cellular Component:  clathrin adaptor complex; cytoplasmic vesicle; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; membrane; membrane coat; trans-Golgi network
Molecular Function:  clathrin binding; protein binding; protein kinase binding
Biological Process:  clathrin coat assembly; determination of left/right symmetry; heart development; intracellular protein transport; protein transport; vesicle-mediated transport
Reference #:  O35643 (UniProtKB)
Alt. Names/Synonyms: Adapter-related protein complex 1 subunit beta-1; Adaptor protein complex AP-1 subunit beta-1; adaptor protein complex AP-1, beta 1 subunit; adaptor-related protein complex AP-1, beta 1 subunit; Adtb1; AP-1 complex subunit beta-1; Ap1b1; Beta-1-adaptin; Beta-adaptin 1; beta-prime adaptin; beta1-adaptin; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit
Gene Symbols: Ap1b1
Molecular weight: 103,935 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene