AP1B1 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes large subunit family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 22q12.2
Cellular Component:  AP-1 adaptor complex; cytoplasmic vesicle membrane; cytosol; early endosome; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; lysosomal membrane; trans-Golgi network membrane
Molecular Function:  clathrin binding; protein binding; protein kinase binding
Biological Process:  basolateral protein secretion; determination of left/right symmetry; heart development; intracellular protein transport; kidney development; melanosome assembly; platelet dense granule organization; vesicle-mediated transport
Disease: Keratitis-ichthyosis-deafness Syndrome, Autosomal Recessive
Reference #:  Q10567 (UniProtKB)
Alt. Names/Synonyms: Adapter-related protein complex 1 subunit beta-1; Adaptor protein complex AP-1 subunit beta-1; adaptor related protein complex 1 beta 1 subunit; adaptor related protein complex 1 subunit beta 1; Adaptor-related protein complex 1 subunit beta-1; adaptor-related protein complex 1, beta 1 subunit; ADTB1; ADTB1, CLAPB2; AP-1 complex subunit beta-1; AP105A; AP1B1; BAM22; Beta-1-adaptin; Beta-adaptin 1; beta-prime-adaptin; beta1-adaptin; CLAPB2; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit; KIDAR; plasma membrane adaptor HA2/AP2 adaptor beta subunit
Gene Symbols: AP1B1
Molecular weight: 104,607 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein