|
AP1B1
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes large subunit family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 22q12.2 |
|
Cellular Component:
AP-1 adaptor complex; cytoplasmic vesicle membrane; cytosol; early endosome; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; lysosomal membrane; trans-Golgi network membrane
|
|
Molecular Function:
clathrin binding; protein binding; protein kinase binding
|
|
Biological Process:
basolateral protein secretion; determination of left/right symmetry; heart development; intracellular protein transport; kidney development; melanosome assembly; platelet dense granule organization; vesicle-mediated transport
|
|
Disease: Keratitis-ichthyosis-deafness Syndrome, Autosomal Recessive
|
|
Reference #:
Q10567
(UniProtKB)
|
|
Alt. Names/Synonyms: Adapter-related protein complex 1 subunit beta-1; Adaptor protein complex AP-1 subunit beta-1; adaptor related protein complex 1 beta 1 subunit; adaptor related protein complex 1 subunit beta 1; Adaptor-related protein complex 1 subunit beta-1; adaptor-related protein complex 1, beta 1 subunit; ADTB1; ADTB1, CLAPB2; AP-1 complex subunit beta-1; AP105A; AP1B1; BAM22; Beta-1-adaptin; Beta-adaptin 1; beta-prime-adaptin; beta1-adaptin; CLAPB2; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit; KIDAR; plasma membrane adaptor HA2/AP2 adaptor beta subunit
|
|
Gene Symbols: AP1B1
|
|
Molecular weight:
104,607 Da
|
|
Basal Isoelectric point:
4.94
Predict pI for various phosphorylation states
|
