DDX15 Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; Nucleolus; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 5|5 C1
Cellular Component:  intracellular anatomical structure; nuclear speck; nucleus; spliceosomal complex; U12-type spliceosomal complex; U2-type post-mRNA release spliceosomal complex
Molecular Function:  ATP binding; double-stranded RNA binding; helicase activity; hydrolase activity; nucleic acid binding; nucleotide binding; protein binding; RNA binding; RNA helicase activity
Biological Process:  antiviral innate immune response; defense response to bacterium; defense response to virus; immune system process; innate immune response; mRNA processing; positive regulation of I-kappaB kinase/NF-kappaB signaling; RNA splicing
Reference #:  O35286 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase DHX15; DBP; DBP1; Ddx15; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A); DEAH (Asp-Glu-Ala-His) box polypeptide 15; DEAH box protein 15; Deah9; Dhx15; HRH; HRH2; mDEAH; mDEAH9; MGC117685; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
Gene Symbols: Dhx15
Molecular weight: 91,007 Da
Basal Isoelectric point: 7.12  Predict pI for various phosphorylation states
Select Structure to View Below

DDX15

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein