GABBR2 Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4|4 B1
Cellular Component:  cell junction; cytoplasm; G protein-coupled receptor heterodimeric complex; GABA receptor complex; GABA-ergic synapse; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; neuron projection; plasma membrane; postsynaptic membrane; synapse
Molecular Function:  G protein-coupled GABA receptor activity; G protein-coupled receptor activity; protein binding; protein heterodimerization activity
Biological Process:  G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; signal transduction
Reference #:  Q80T41 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor 51; G-protein coupled receptor 51; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gabbr2; GABR2; gamma-aminobutyric acid (GABA) B receptor, 2; Gamma-aminobutyric acid type B receptor subunit 2; gamma-aminobutyric acid type B receptor, subunit 2; Gb2; Gm425; Gpr51; ortholog of human G protein-coupled receptor 51 GPR51; OTTMUSP00000007177
Gene Symbols: Gabbr2
Molecular weight: 105,666 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene