GGA3
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation. Modulates BACE1 protein levels intedepently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination. Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane. Belongs to the GGA protein family. Ubiquitously expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Vesicle |
Chromosomal Location of human Ortholog: 17q25.1 |
Cellular Component:
early endosome membrane; endosome membrane; Golgi apparatus; lysosome; protein-containing complex; recycling endosome membrane; trans-Golgi network
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Molecular Function:
phosphatidylinositol binding; protein binding; protein-containing complex binding; small GTPase binding; ubiquitin binding
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Biological Process:
endocytic recycling; Golgi to plasma membrane protein transport; Golgi to plasma membrane transport; intracellular protein transport; negative regulation of amyloid-beta formation; positive regulation of protein catabolic process; protein catabolic process; protein destabilization; protein localization to cell surface; protein targeting to lysosome; regulation of protein stability
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Reference #:
Q9NZ52
(UniProtKB)
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Alt. Names/Synonyms: ADP-ribosylation factor-binding protein GGA3; GGA3; golgi associated, gamma adaptin ear containing, ARF binding protein 3; golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Golgi-localized, gamma ear-containing, ARF-binding protein 3; KIAA0154
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Gene Symbols: GGA3
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Molecular weight:
78,315 Da
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Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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