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FOXO1A
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor |
| Chromosomal Location of rat Ortholog: 2q26 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; promoter-specific chromatin binding; protein phosphatase 2A binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator binding; ubiquitin protein ligase binding
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Biological Process:
apoptotic process; autophagy; blood vessel development; canonical Wnt signaling pathway; cell differentiation; cellular response to dexamethasone stimulus; cellular response to hydrogen peroxide; cellular response to hyperoxia; cellular response to insulin stimulus; cellular response to nitric oxide; cellular response to oxidative stress; cellular response to starvation; DNA damage response; enamel mineralization; gene expression; glucose homeostasis; insulin receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of insulin secretion; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; neuronal stem cell population maintenance; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of complement-dependent cytotoxicity; positive regulation of DNA-templated transcription; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription by RNA polymerase II; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of gluconeogenesis; regulation of neural precursor cell proliferation; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II; response to fatty acid; response to fluoride; response to insulin
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Reference #:
G3V7R4
(UniProtKB)
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Alt. Names/Synonyms: Fkhr; forkhead box O1; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Foxo1; Foxo1a; Transcription factor FKHR
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Gene Symbols: Foxo1
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Molecular weight:
69,344 Da
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Basal Isoelectric point:
6.47
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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B Cell Receptor Signaling
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ErbB/HER Signaling
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G1/S Checkpoint
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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