FOXO1A a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 2q26
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  beta-catenin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein phosphatase 2A binding; sequence-specific DNA binding; transcription coactivator binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process:  apoptotic process; autophagy; blood vessel development; cell differentiation; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to hydrogen peroxide; cellular response to hyperoxia; cellular response to insulin stimulus; cellular response to nitric oxide; cellular response to oxidative stress; cellular response to starvation; enamel mineralization; glucose homeostasis; insulin receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; neuronal stem cell population maintenance; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of complement-dependent cytotoxicity; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of cell proliferation; regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter; regulation of neural precursor cell proliferation; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to fluoride; response to insulin
Reference #:  G3V7R4 (UniProtKB)
Alt. Names/Synonyms: Fkhr; forkhead box O1; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Foxo1; Foxo1a; Transcription factor FKHR
Gene Symbols: Foxo1
Molecular weight: 69,344 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  G1/S Checkpoint  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein