PDE3A Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 6|6 G2
Cellular Component:  cytosol; integral component of membrane; membrane
Molecular Function:  3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity
Biological Process:  cAMP-mediated signaling; cellular response to cGMP; cGMP-mediated signaling; negative regulation of apoptotic process; negative regulation of cAMP-mediated signaling; negative regulation of vascular permeability; oocyte maturation; positive regulation of oocyte development; positive regulation of vascular permeability; regulation of meiotic nuclear division; response to drug; signal transduction
Reference #:  Q9Z0X4 (UniProtKB)
Alt. Names/Synonyms: A930022O17Rik; C87899; CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited phosphodiesterase; Cyclic GMP-inhibited phosphodiesterase A; Pde3a; phosphodiesterase 3A, cGMP inhibited
Gene Symbols: Pde3a
Molecular weight: 124,513 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
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PDE3A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene