PDE3A Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 12p12.2
Cellular Component:  cytosol; integral component of membrane
Molecular Function:  cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein binding
Biological Process:  cAMP-mediated signaling; cellular response to cGMP; cellular response to transforming growth factor beta stimulus; cGMP-mediated signaling; G protein-coupled receptor signaling pathway; lipid metabolic process; negative regulation of apoptotic process; negative regulation of cAMP-mediated signaling; negative regulation of vascular permeability; positive regulation of vascular permeability; regulation of meiotic nuclear division; response to drug
Disease: Hypertension And Brachydactyly Syndrome
Reference #:  Q14432 (UniProtKB)
Alt. Names/Synonyms: CGI-PDE; CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cyclic GMP inhibited phosphodiesterase A; Cyclic GMP-inhibited phosphodiesterase A; PDE3A; phosphodiesterase 3A, cGMP-inhibited
Gene Symbols: PDE3A
Molecular weight: 124,979 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
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PDE3A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB