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CRMP-4 iso2
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Hydrolase |
| Chromosomal Location of human Ortholog: 5q32 |
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Cellular Component:
cell body; cytosol; exocytic vesicle; extracellular space; filamentous actin; growth cone; lamellipodium; synapse
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Molecular Function:
chondroitin sulfate binding; dihydropyrimidinase activity; filamin binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; identical protein binding; protein binding; SH3 domain binding
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Biological Process:
actin crosslink formation; actin filament bundle assembly; cellular response to cytokine stimulus; negative regulation of cell migration; negative regulation of neuron projection development; neuron development; positive regulation of filopodium assembly; positive regulation of neuron projection development; pyrimidine nucleobase catabolic process; response to axon injury
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Reference #:
Q14195-2
(UniProtKB)
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Alt. Names/Synonyms: Collapsin response mediator protein 4; collapsin response mediator protein 4 long; CRMP-4; CRMP-4 iso2; CRMP4; dihydropyrimidinase like 3; dihydropyrimidinase-like 3; Dihydropyrimidinase-related protein 3; DPYL3; DPYSL3; DRP-3; DRP3; LCRMP; testicular secretory protein Li 7; ULIP; ULIP-1; ULIP1; Unc-33-like phosphoprotein 1
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Gene Symbols: DPYSL3
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Molecular weight:
73,910 Da
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Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
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