SV2A
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. Belongs to the major facilitator superfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Vesicle |
Chromosomal Location of human Ortholog: 1q21.2 |
Cellular Component:
cell-cell junction; dendrite; endoplasmic reticulum; GABA-ergic synapse; glutamatergic synapse; neuromuscular junction; neuron projection; neuronal cell body; plasma membrane; presynaptic active zone; synaptic vesicle; synaptic vesicle membrane
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Molecular Function:
protein kinase binding; transmembrane transporter activity
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Biological Process:
intracellular calcium ion homeostasis; regulation of gamma-aminobutyric acid secretion; synaptic vesicle priming; transmembrane transport
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Disease: Developmental And Epileptic Encephalopathy 113
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Reference #:
Q7L0J3
(UniProtKB)
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Alt. Names/Synonyms: KIAA0736; SV2; SV2A; synaptic vesicle glycoprotein 2; Synaptic vesicle glycoprotein 2A
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Gene Symbols: SV2A
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Molecular weight:
82,695 Da
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Basal Isoelectric point:
5.38
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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