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C1QA iso2
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 1p36.12 |
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Cellular Component:
collagen trimer; complement component C1 complex; complement component C1q complex; extracellular region; postsynapse; synapse
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Molecular Function:
amyloid-beta binding; protein binding
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Biological Process:
aging; astrocyte activation; cell-cell signaling; complement activation; complement activation, classical pathway; complement-mediated synapse pruning; innate immune response; microglial cell activation; neuron remodeling; positive regulation of neuron death; synapse organization; synapse pruning; vertebrate eye-specific patterning
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Reference #:
Q9H2L7
(UniProtKB)
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Alt. Names/Synonyms: C1QA; C1QA iso2; complement C1q A chain; complement C1q chain A; complement C1q subcomponent subunit A; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain; DC33
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Gene Symbols: C1QA
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Molecular weight:
29,546 Da
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Basal Isoelectric point:
11.38
Predict pI for various phosphorylation states
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