PDX1 Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5 G3|5 86.84 cM
Cellular Component:  cytoplasm; nuclear speck; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; protein-containing complex binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  cell differentiation; detection of glucose; digestive tract development; endocrine pancreas development; exocrine pancreas development; glucose homeostasis; glucose metabolic process; insulin secretion; liver development; morphogenesis of embryonic epithelium; multicellular organism development; negative regulation of cell proliferation; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of type B pancreatic cell apoptotic process; nitric oxide mediated signal transduction; pancreas development; positive regulation of cell death; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of insulin secretion; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of cell proliferation; regulation of gene expression; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to glucose; smoothened signaling pathway; stem cell differentiation; transcription by RNA polymerase II; transcription, DNA-templated; type B pancreatic cell differentiation
Reference #:  P52946 (UniProtKB)
Alt. Names/Synonyms: IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; IPF-1; Ipf1; Islet/duodenum homeobox 1; Mody4; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox 1; pancreatic and duodenal homeobox gene 1; pdx-1; Pdx1; Somatostatin-transactivating factor 1; STF-1
Gene Symbols: Pdx1
Molecular weight: 30,999 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDX1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene