TAF1B Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Belongs to the RRN7/TAF1B family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; Transcription initiation complex
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component:  nucleoplasm; nucleus; RNA polymerase I core factor complex
Molecular Function:  metal ion binding; protein binding; RNA polymerase I CORE element sequence-specific DNA binding; TBP-class protein binding
Biological Process:  positive regulation of gene expression, epigenetic; RNA polymerase I preinitiation complex assembly; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter; transcription, DNA-templated
Reference #:  Q53T94 (UniProtKB)
Alt. Names/Synonyms: MGC:9349; RAF1B; RAFI63; RNA polymerase I-specific TBP-associated factor 63 kDa; SL1; SL1, 63kD subunit; TAF1B; TAFI63; TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kD; TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; TATA box-binding protein-associated factor 1B; TATA box-binding protein-associated factor RNA polymerase I subunit B; TATA-box binding protein associated factor, RNA polymerase I subunit B; TATA-box binding protein associated factor, RNA polymerase I, B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B
Gene Symbols: TAF1B
Molecular weight: 68,832 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
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TAF1B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene