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IFNAR1
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. Belongs to the type II cytokine receptor family. IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of human Ortholog: 21q22.11 |
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Cellular Component:
late endosome; lysosome; plasma membrane
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Molecular Function:
cytokine binding; cytokine receptor activity; protein binding; type I interferon binding; type I interferon receptor activity
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Biological Process:
cellular response to interferon-alpha; cellular response to virus; cytokine-mediated signaling pathway; positive regulation of cellular respiration; receptor signaling pathway via JAK-STAT; response to lipopolysaccharide; response to virus; type I interferon-mediated signaling pathway
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Disease: Immunodeficiency 106, Susceptibility To Viral Infections
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Reference #:
P17181
(UniProtKB)
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Alt. Names/Synonyms: alpha-type antiviral protein; AVP; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN-alpha-REC; IFN-alpha/beta receptor 1; IFN-R-1; IFNAR; IFNAR1; IFNBR; IFRC; INAR1; interferon (alpha, beta and omega) receptor 1; interferon alpha and beta receptor subunit 1; Interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1
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Gene Symbols: IFNAR1
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Molecular weight:
63,525 Da
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Basal Isoelectric point:
5.58
Predict pI for various phosphorylation states
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CST Pathways:
PI3K/Akt Signaling
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