IFNAR1 Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. Belongs to the type II cytokine receptor family. IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of human Ortholog: 21q22.11
Cellular Component:  late endosome; lysosome; plasma membrane
Molecular Function:  cytokine binding; cytokine receptor activity; protein binding; type I interferon binding; type I interferon receptor activity
Biological Process:  cellular response to interferon-alpha; cellular response to virus; cytokine-mediated signaling pathway; positive regulation of cellular respiration; receptor signaling pathway via JAK-STAT; response to lipopolysaccharide; response to virus; type I interferon-mediated signaling pathway
Disease: Immunodeficiency 106, Susceptibility To Viral Infections
Reference #:  P17181 (UniProtKB)
Alt. Names/Synonyms: alpha-type antiviral protein; AVP; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN-alpha-REC; IFN-alpha/beta receptor 1; IFN-R-1; IFNAR; IFNAR1; IFNBR; IFRC; INAR1; interferon (alpha, beta and omega) receptor 1; interferon alpha and beta receptor subunit 1; Interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1
Gene Symbols: IFNAR1
Molecular weight: 63,525 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB