TIA1 Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 6|6 D1
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytosol; nuclear stress granule; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  mRNA 3'-UTR AU-rich region binding; nucleic acid binding; protein binding; RNA binding
Biological Process:  apoptotic process; negative regulation of cytokine biosynthetic process; negative regulation of translation; positive regulation of epithelial cell apoptotic process; protein localization to cytoplasmic stress granule; regulation of mRNA splicing, via spliceosome
Reference #:  P52912 (UniProtKB)
Alt. Names/Synonyms: 2310050N03Rik; AI256674; cytotoxic granule-associated RNA binding protein 1; cytotoxic granule-associated RNA-binding protein 1; mTIA-1; Nucleolysin TIA-1; OTTMUSP00000026222; RNA-binding protein TIA-1; Tia; Tia1
Gene Symbols: Tia1
Molecular weight: 42,800 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene