CASP2 Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Chromosomal Location of Human Ortholog: 6 B2.1|6 20.54 cM
Cellular Component:  cytoplasm; membrane; mitochondrion; nucleus
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; hydrolase activity; identical protein binding; peptidase activity; protein binding; protein domain specific binding
Biological Process:  apoptotic process; apoptotic signaling pathway; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of apoptotic process; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of apoptotic process
Reference #:  P29594 (UniProtKB)
Alt. Names/Synonyms: CASP-2; Casp2; caspase 2; Caspase-2; Caspase-2 subunit p12; Caspase-2 subunit p13; Caspase-2 subunit p18; Caspase2; ICH-1; Ich1; NEDD-2; Nedd2; Neural precursor cell expressed developmentally down-regulated protein 2; OTTMUSP00000027875; Protease ICH-1
Gene Symbols: Casp2
Molecular weight: 50,661 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling  |  Mitochondrial Control of Apoptosis
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene