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CASP2
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Belongs to the peptidase C14A family. Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; EC 3.4.22.55; Protease |
| Chromosomal Location of mouse Ortholog: 6 B2.1|6 20.54 cM |
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Cellular Component:
caspase complex; cytoplasm; endopeptidase complex; nucleolus; nucleus
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Molecular Function:
cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; hydrolase activity; identical protein binding; peptidase activity; protein binding; protein domain specific binding
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; apoptotic signaling pathway; DNA damage response; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of apoptotic process; negative regulation of necroptotic process; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of apoptotic process; regulation of DNA stability; release of cytochrome c from mitochondria
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Reference #:
P29594
(UniProtKB)
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Alt. Names/Synonyms: Casp; CASP-2; Casp2; caspase 2; Caspase-2; Caspase-2 subunit p12; Caspase-2 subunit p13; Caspase-2 subunit p18; Caspase2; Ich-; ICH-1; Ich1; Nedd; NEDD-2; Nedd2; Neural precursor cell expressed developmentally down-regulated protein 2; OTTMUSP00000027875; Protease ICH-1
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Gene Symbols: Casp2
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Molecular weight:
50,661 Da
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Basal Isoelectric point:
6.06
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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ErbB/HER Signaling
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Mitochondrial Control of Apoptosis
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