5-HT(6) This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of TOR signaling. Belongs to the G-protein coupled receptor 1 family. Expressed in several human brain regions, most prominently in the caudate nucleus. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q36
Cellular Component:  cilium; dendrite; integral component of membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity
Biological Process:  brain development; cerebral cortex cell migration; chemical synaptic transmission; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G protein-coupled serotonin receptor signaling pathway; learning; long-term synaptic potentiation; negative regulation of acetylcholine secretion, neurotransmission; negative regulation of gamma-aminobutyric acid secretion; negative regulation of glutamate secretion; positive regulation of dopamine secretion; positive regulation of gamma-aminobutyric acid secretion; positive regulation of TOR signaling; response to drug; response to estradiol
Reference #:  P31388 (UniProtKB)
Alt. Names/Synonyms: 5-HT(6); 5-HT-6; 5-HT6; 5-hydroxytryptamine (serotonin) receptor 6; 5-hydroxytryptamine receptor 6; 5HT6R; Htr6; Serotonin receptor 6; ST-B17
Gene Symbols: Htr6
Molecular weight: 46,923 Da
Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene