SCARB1 iso2 Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate. Mediates uptake of M.fortuitum, E.coli and S.aureus. Belongs to the CD36 family. Widely expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component:  caveola; cell surface; endocytic vesicle membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; microvillus membrane; plasma membrane
Molecular Function:  1-phosphatidylinositol binding; amyloid-beta binding; apolipoprotein A-I binding; apolipoprotein binding; high-density lipoprotein particle binding; high-density lipoprotein particle receptor activity; lipopolysaccharide binding; lipopolysaccharide receptor activity; low-density lipoprotein particle binding; phosphatidylserine binding; protein binding; protein homodimerization activity; scavenger receptor activity; virus receptor activity
Biological Process:  adhesion of symbiont to host; androgen biosynthetic process; blood vessel endothelial cell migration; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol import; detection of lipopolysaccharide; endothelial cell proliferation; high-density lipoprotein particle clearance; high-density lipoprotein particle remodeling; intestinal absorption; lipopolysaccharide transport; lipopolysaccharide-mediated signaling pathway; low-density lipoprotein particle clearance; phospholipid transport; positive regulation of cholesterol storage; positive regulation of endothelial cell migration; positive regulation of nitric-oxide synthase activity; positive regulation of triglyceride biosynthetic process; receptor-mediated endocytosis; recognition of apoptotic cell; regulation of phagocytosis; regulation of phosphatidylcholine catabolic process; reverse cholesterol transport; triglyceride homeostasis; viral entry into host cell; vitamin transmembrane transport; wound healing
Disease: High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6
Reference #:  Q8WTV0-2 (UniProtKB)
Alt. Names/Synonyms: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CD36L1; CLA-1; CLA1; Collagen type I receptor, thrombospondin receptor-like 1; HDLQTL6; MGC138242; SCARB1; SCARB1 iso2; Scavenger receptor class B member 1; scavenger receptor class B type 1; scavenger receptor class B type III; scavenger receptor class B, member 1; SCRB1; SR-BI; SRB1
Gene Symbols: SCARB1
Molecular weight: 56,973 Da
Basal Isoelectric point: 8.17  Predict pI for various phosphorylation states
Select Structure to View Below

SCARB1 iso2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein