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SCARB1 iso2
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate. Mediates uptake of M.fortuitum, E.coli and S.aureus. Belongs to the CD36 family. Widely expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. |
| Chromosomal Location of human Ortholog: 12q24.31 |
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Cellular Component:
caveola; cell surface; cytoplasm; endocytic vesicle membrane; intracellular membrane-bounded organelle; lysosome; plasma membrane
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Molecular Function:
1-phosphatidylinositol binding; amyloid-beta binding; apolipoprotein A-I binding; apolipoprotein binding; high-density lipoprotein particle binding; high-density lipoprotein particle receptor activity; lipid binding; lipopolysaccharide binding; lipopolysaccharide immune receptor activity; low-density lipoprotein particle binding; phosphatidylserine binding; protein binding; scavenger receptor activity; virus receptor activity
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Biological Process:
adhesion of symbiont to host; blood vessel endothelial cell migration; carotenoid transport; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol import; detection of lipopolysaccharide; endothelial cell proliferation; high-density lipoprotein particle clearance; high-density lipoprotein particle remodeling; intestinal lipid absorption; lipopolysaccharide transport; lipopolysaccharide-mediated signaling pathway; low-density lipoprotein particle clearance; phospholipid transport; plasma lipoprotein particle clearance; positive regulation of cholesterol storage; positive regulation of endothelial cell migration; positive regulation of nitric-oxide synthase activity; positive regulation of triglyceride biosynthetic process; recognition of apoptotic cell; regulation of phagocytosis; regulation of phosphatidylcholine catabolic process; reverse cholesterol transport; triglyceride homeostasis; viral entry into host cell; vitamin transmembrane transport; wound healing
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Disease: High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6
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Reference #:
Q8WTV0-2
(UniProtKB)
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Alt. Names/Synonyms: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CD36L1; CLA-1; CLA1; Collagen type I receptor, thrombospondin receptor-like 1; HDLQTL6; MGC138242; SCARB1; SCARB1 iso2; Scavenger receptor class B member 1; scavenger receptor class B type 1; scavenger receptor class B type III; scavenger receptor class B, member 1; SCRB1; SR-BI; SRB1
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Gene Symbols: SCARB1
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Molecular weight:
56,973 Da
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Basal Isoelectric point:
8.17
Predict pI for various phosphorylation states
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