MAP2 iso2 The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 2q34
Cellular Component:  apical distal dendrite; axon hillock; axon initial segment; basal dendrite; cytoplasm; cytosol; dendrite; dendrite cytoplasm; dendritic branch; dendritic filopodium; dendritic growth cone; dendritic shaft; distal dendrite; main axon; microtubule; microtubule associated complex; neuron projection; neuronal cell body; primary dendrite; proximal dendrite; proximal neuron projection
Molecular Function:  calmodulin binding; dystroglycan binding; microtubule binding; protein binding; structural molecule activity; tau protein binding
Biological Process:  central nervous system neuron development; dendrite development; dendrite morphogenesis; microtubule cytoskeleton organization; negative regulation of axon extension; negative regulation of microtubule binding; negative regulation of microtubule polymerization; neuron projection development; positive regulation of anterograde dense core granule transport; positive regulation of anterograde synaptic vesicle transport; regulation of microtubule polymerization; regulation of organelle transport along microtubule; regulation of protein localization
Reference #:  P11137-2 (UniProtKB)
Alt. Names/Synonyms: DKFZp686I2148; MAP-2; MAP2; MAP2 iso2; MAP2A; MAP2B; MAP2C; microtubule associated protein 2; Microtubule-associated protein 2; MTAP2
Gene Symbols: MAP2
Molecular weight: 49,640 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MAP2 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Protein Atlas  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein