Bcl-11A Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex. Repressor of fetal hemoglobin (HbF) level. Involved in brain development. Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component:  cytoplasm; nucleoplasm; postsynaptic density
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  cellular response to L-glutamate; negative regulation of branching morphogenesis of a nerve; negative regulation of dendrite development; negative regulation of dendrite extension; negative regulation of neuron remodeling; negative regulation of transcription by RNA polymerase II; positive regulation of gene expression; protein sumoylation
Disease: Intellectual Developmental Disorder With Persistence Of Fetal Hemoglobin
Reference #:  Q9H165 (UniProtKB)
Alt. Names/Synonyms: B cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell lymphoma/leukemia 11A; BAF chromatin remodeling complex subunit BCL11A; BC11A; BCL-11A; BCL11A; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein); BCL11A, BAF complex component; BCL11A-L; BCL11a-M; BCL11A-S; BCL11A-XL; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; CTIP1; DILOS; ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein homolog; EVI-9; EVI9; FLJ10173; FLJ34997; HBFQTL5; KIAA1809; Zinc finger protein 856; ZNF856
Gene Symbols: BCL11A
Molecular weight: 91,197 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Bcl-11A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA